The treatments available fall into three groups (Fig. 3.17): (i) surgery, via the transsphenoidal or transfrontal route; (ii) radiotherapy using a linear accelerator, a cobalt source or a proton beam, and (iii) medical therapy using a long-acting somatostatin analogue (e.g. octreotide) or a dopamine agonist (e.g. bromocriptine ) .